Last update:
   15-Sep-2021
 

Arch Hellen Med, 38(5), September-October 2021, 618-623

ORIGINAL PAPER

Racecadotril for treating acute diarrhea in children
A systematic review and meta-analysis

F. Farahdina,1 F. Rizaliansyah,2 J.U. Aulya,3 J.K. Fajar4
1Faculty of Medicine, Universitas Brawijaya, Malang
2Faculty of Medicine, Universitas Airlangga, Surabaya
3Faculty of Medicine, Universitas Sumatera Utara, Medan
4Brawijaya Internal Medicine Research Center, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia

OBJECTIVE To perform a review and meta-analysis concerning the efficacy of racecadotril administration for treating acute diarrhea in children.

METHOD Published papers selected from PubMed, Embase, Cochrane, and Google Scholar were analyzed using a fixed or random-effect model.

RESULTS A total of 11 relevant papers were included in the analysis, which showed that racecadotril administration, compared with control, was associated with reduced duration of diarrhea, with standardized mean difference (SMD): 0.98 (95% CI: 0.55–1.43, p<0.001) and stool volume, SMD: 4.93 (95% CI: 2.98–7.0, p=0.000). Conversely, dehydration (OR: 1.78 [95% CI: 0.70–4.53], p=0.226) and vomiting (OR: 1.44 [95% CI: 0.98–2.12], p=0.066) were not affected significantly by treatment with racecadotril.

CONCLUSIONS Racecadotril administration appears to reduce diarrhea duration and stool volume in children with acute diarrhea.

Key words: Acute diarrhea, Adjuvant therapy, Racecadotril.

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