Last update:
   05-Dec-2022
 

Arch Hellen Med, 39(6),November-December 2022, 819-826

ORIGINAL PAPER

Correlation between bile reflux gastropathy and therapeutic biliary interventions

A. Othman,1 A. Dwedar,2 H. El Sadek,2 H. Abd El Aziz,3 A. Abdelrahman4
1Department of Internal Medicine, Faculty of Medicine, Suez University, Suez
2Department of Internal Medicine, Faculty of Medicine, Zagazig University, Zagazig
3Department of Pathology, Faculty of Medicine, Zagazig University, Zagazig
4Department of Clinical Pathology, Faculty of Medicine, Zagazig University, Zagazig, Egypt

OBJECTIVE To determine whether therapeutic biliary procedures induce bile reflux gastropathy, to estimate its prevalence and risk factors and to assess the endoscopic and histopathological changes in the gastric mucosa.

METHOD Study was made of 62 patients with epigastric pain and or dyspeptic symptoms following biliary intervention, who were divided into two groups: Group 1, the post-cholecystectomy group, consisted of 34 patients who had undergone cholecystectomy, and group 2, the biliary intervention group, of 28 patients who had undergone endoscopic retrograde cholangiopancreatography (ERCP) for treatment of benign pathology.

RESULTS The prevalence of bile reflux gastropathy was 21.34% after therapeutic biliary interventions (p=0.00). Diabetes mellitus (DM), obesity, high gastric bilirubin level and increased gastric pH were all risk factors for bile reflux gastropathy in both groups (r=0.27, 0.31, 0.68, and 0.59, respectively). No correlation was demonstrated between age, sex, epigastric pain, heartburn, vomiting, and bile reflux gastropathy.

CONCLUSIONS Bile reflux gastropathy is common after therapeutic biliary interventions and is more frequent in patients with obesity and DM.

Key words: Bile reflux, Bilirubin, Cholecystectomy, ERCP, Gastropathy.

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