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29-Sep-2025
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Arch Hellen Med, 42(6), November-December 2025, 799-809 ORIGINAL PAPER The infectious complications of ABO incompatibility in renal transplant patients S.M.D. Natasia,1 A. Evatta,2 M. Setiawan,3 J.K. Fajar,4 D.S.B. Santoso5 |
OBJECTIVE To evaluate the impact and types of infections in ABO-incompatible kidney transplant patients.
METHOD The study was a meta-analysis. The search strategy utilized databases such as Embase, Scopus, and PubMed. We conducted our study between July and August 2024 and we collected data on the occurrence of infection complications in kidney transplant patients with ABO incompatibility. The data were calculated with the aim to determine the cumulative effect estimate. We used the Mantel-Haenszel test to analyze the data.
RESULTS Thirty-one articles were included comprising 2,114 patients with ABO incompatibility and 32,287 patients with ABO compatibility. Our results indicated that patients with ABO incompatibility undergoing kidney transplantation had a 1.49 times higher risk of infection compared to those with ABO compatibility. More specifically, the types of infections that increased in ABO incompatible kidney transplant patients included sepsis, cytomegalovirus (CMV) infection, BK virus (BKV) infection, herpes zoster virus (HZV) infection, and pneumonia. However, we could not establish a link between urinary tract infections (UTIs) and Pneumocystis pneumonia (PCP) occurrences in ABO incompatible kidney transplant patients.
CONCLUSIONS ABO incompatibility in kidney transplant patients has a crucial impact on causing infection complications.
Key words: ABO incompatibility, Complication, Infection, Kidney transplant, Predictor.
